Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial.
Identifieur interne : 000840 ( Main/Exploration ); précédent : 000839; suivant : 000841Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial.
Auteurs : Sung Won Choi [États-Unis] ; Thomas Braun [États-Unis] ; Lawrence Chang [États-Unis] ; James L M. Ferrara [États-Unis] ; Attaphol Pawarode [États-Unis] ; John M. Magenau [États-Unis] ; Guoqing Hou [États-Unis] ; Jan H. Beumer [États-Unis] ; John E. Levine [États-Unis] ; Steve Goldstein [États-Unis] ; Daniel R. Couriel [États-Unis] ; Keith Stockerl-Goldstein [États-Unis] ; Oleg I. Krijanovski [États-Unis] ; Carrie Kitko [États-Unis] ; Gregory A. Yanik [États-Unis] ; Michael H. Lehmann [États-Unis] ; Isao Tawara [Japon] ; Yaping Sun [États-Unis] ; Sophie Paczesny [États-Unis] ; Markus Y. Mapara [États-Unis] ; Charles A. Dinarello [Pays-Bas] ; John F. Dipersio [États-Unis] ; Pavan Reddy [États-Unis]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2014.
Descripteurs français
- KwdFr :
- Acide mycophénolique (administration et posologie), Acide mycophénolique (analogues et dérivés), Acides hydroxamiques (administration et posologie), Adulte, Adulte d'âge moyen, Conditionnement pour greffe, Femelle, Humains, Immunosuppresseurs (administration et posologie), Inhibiteurs de désacétylase d'histone (administration et posologie), Maladie aigüe, Maladie du greffon contre l'hôte (), Mâle, Sujet âgé, Tacrolimus (administration et posologie), Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études prospectives.
- MESH :
- administration et posologie : Acide mycophénolique, Acides hydroxamiques, Immunosuppresseurs, Inhibiteurs de désacétylase d'histone, Tacrolimus.
- analogues et dérivés : Acide mycophénolique.
- Adulte, Adulte d'âge moyen, Conditionnement pour greffe, Femelle, Humains, Maladie aigüe, Maladie du greffon contre l'hôte, Mâle, Sujet âgé, Transplantation de cellules souches hématopoïétiques, Transplantation homologue, Études prospectives.
English descriptors
- KwdEn :
- Acute Disease, Adult, Aged, Female, Graft vs Host Disease (prevention & control), Hematopoietic Stem Cell Transplantation, Histone Deacetylase Inhibitors (administration & dosage), Humans, Hydroxamic Acids (administration & dosage), Immunosuppressive Agents (administration & dosage), Male, Middle Aged, Mycophenolic Acid (administration & dosage), Mycophenolic Acid (analogs & derivatives), Prospective Studies, Tacrolimus (administration & dosage), Transplantation Conditioning, Transplantation, Homologous.
- MESH :
- chemical , administration & dosage : Histone Deacetylase Inhibitors, Hydroxamic Acids, Immunosuppressive Agents, Mycophenolic Acid, Tacrolimus.
- chemical , analogs & derivatives : Mycophenolic Acid.
- prevention & control : Graft vs Host Disease.
- Acute Disease, Adult, Aged, Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Prospective Studies, Transplantation Conditioning, Transplantation, Homologous.
Abstract
Acute graft-versus-host disease (GVHD) remains a barrier to more widespread application of allogeneic haemopoietic stem-cell transplantation. Vorinostat is an inhibitor of histone deacetylases and was shown to attenuate GVHD in preclinical models. We aimed to study the safety and activity of vorinostat, in combination with standard immunoprophylaxis, for prevention of GVHD in patients undergoing related-donor reduced-intensity conditioning haemopoietic stem-cell transplantation.
DOI: 10.1016/S1470-2045(13)70512-6
PubMed: 24295572
Affiliations:
- Japon, Pays-Bas, États-Unis
- Californie, Indiana, Michigan, Missouri (État), Pennsylvanie, État de New York
- New York, Pittsburgh
- Université Columbia, Université de Pittsburgh
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Le document en format XML
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Mapara</name><affiliation wicri:level="4"><nlm:affiliation>Blood and Marrow Transplantation Program, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Dinarello, Charles A" sort="Dinarello, Charles A" uniqKey="Dinarello C" first="Charles A" last="Dinarello">Charles A. Dinarello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Colorado, Aurora, CO, USA; Department of Medicine, University Medical Center Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medicine, University of Colorado, Aurora, CO, USA; Department of Medicine, University Medical Center Nijmegen</wicri:regionArea><wicri:noRegion>University Medical Center Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Dipersio, John F" sort="Dipersio, John F" uniqKey="Dipersio J" first="John F" last="Dipersio">John F. Dipersio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA. 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Ferrara</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Pawarode, Attaphol" sort="Pawarode, Attaphol" uniqKey="Pawarode A" first="Attaphol" last="Pawarode">Attaphol Pawarode</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Magenau, John M" sort="Magenau, John M" uniqKey="Magenau J" first="John M" last="Magenau">John M. Magenau</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Hou, Guoqing" sort="Hou, Guoqing" uniqKey="Hou G" first="Guoqing" last="Hou">Guoqing Hou</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Beumer, Jan H" sort="Beumer, Jan H" uniqKey="Beumer J" first="Jan H" last="Beumer">Jan H. Beumer</name><affiliation wicri:level="4"><nlm:affiliation>Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Levine, John E" sort="Levine, John E" uniqKey="Levine J" first="John E" last="Levine">John E. Levine</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Goldstein, Steve" sort="Goldstein, Steve" uniqKey="Goldstein S" first="Steve" last="Goldstein">Steve Goldstein</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R" last="Couriel">Daniel R. Couriel</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Stockerl Goldstein, Keith" sort="Stockerl Goldstein, Keith" uniqKey="Stockerl Goldstein K" first="Keith" last="Stockerl-Goldstein">Keith Stockerl-Goldstein</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, Washington University, St Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, Washington University, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Krijanovski, Oleg I" sort="Krijanovski, Oleg I" uniqKey="Krijanovski O" first="Oleg I" last="Krijanovski">Oleg I. Krijanovski</name><affiliation wicri:level="2"><nlm:affiliation>Sutter East Bay Medical Foundation, Berkeley, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sutter East Bay Medical Foundation, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kitko, Carrie" sort="Kitko, Carrie" uniqKey="Kitko C" first="Carrie" last="Kitko">Carrie Kitko</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Yanik, Gregory A" sort="Yanik, Gregory A" uniqKey="Yanik G" first="Gregory A" last="Yanik">Gregory A. Yanik</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Lehmann, Michael H" sort="Lehmann, Michael H" uniqKey="Lehmann M" first="Michael H" last="Lehmann">Michael H. Lehmann</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Tawara, Isao" sort="Tawara, Isao" uniqKey="Tawara I" first="Isao" last="Tawara">Isao Tawara</name><affiliation wicri:level="1"><nlm:affiliation>Hematology-Oncology, Mie University Hospital, Mie, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Hematology-Oncology, Mie University Hospital, Mie</wicri:regionArea><wicri:noRegion>Mie</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yaping" sort="Sun, Yaping" uniqKey="Sun Y" first="Yaping" last="Sun">Yaping Sun</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Paczesny, Sophie" sort="Paczesny, Sophie" uniqKey="Paczesny S" first="Sophie" last="Paczesny">Sophie Paczesny</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Hematology Oncology, Indiana University, Indianapolis, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pediatric Hematology Oncology, Indiana University, Indianapolis, IN</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Mapara, Markus Y" sort="Mapara, Markus Y" uniqKey="Mapara M" first="Markus Y" last="Mapara">Markus Y. Mapara</name><affiliation wicri:level="4"><nlm:affiliation>Blood and Marrow Transplantation Program, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Dinarello, Charles A" sort="Dinarello, Charles A" uniqKey="Dinarello C" first="Charles A" last="Dinarello">Charles A. Dinarello</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Colorado, Aurora, CO, USA; Department of Medicine, University Medical Center Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medicine, University of Colorado, Aurora, CO, USA; Department of Medicine, University Medical Center Nijmegen</wicri:regionArea><wicri:noRegion>University Medical Center Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Dipersio, John F" sort="Dipersio, John F" uniqKey="Dipersio J" first="John F" last="Dipersio">John F. Dipersio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cardiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cardiology, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA. Electronic address: reddypr@umich.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adult</term><term>Aged</term><term>Female</term><term>Graft vs Host Disease (prevention & control)</term><term>Hematopoietic Stem Cell Transplantation</term><term>Histone Deacetylase Inhibitors (administration & dosage)</term><term>Humans</term><term>Hydroxamic Acids (administration & dosage)</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Mycophenolic Acid (administration & dosage)</term><term>Mycophenolic Acid (analogs & derivatives)</term><term>Prospective Studies</term><term>Tacrolimus (administration & dosage)</term><term>Transplantation Conditioning</term><term>Transplantation, Homologous</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide mycophénolique (administration et posologie)</term><term>Acide mycophénolique (analogues et dérivés)</term><term>Acides hydroxamiques (administration et posologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Conditionnement pour greffe</term><term>Femelle</term><term>Humains</term><term>Immunosuppresseurs (administration et posologie)</term><term>Inhibiteurs de désacétylase d'histone (administration et posologie)</term><term>Maladie aigüe</term><term>Maladie du greffon contre l'hôte ()</term><term>Mâle</term><term>Sujet âgé</term><term>Tacrolimus (administration et posologie)</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Transplantation homologue</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Histone Deacetylase Inhibitors</term><term>Hydroxamic Acids</term><term>Immunosuppressive Agents</term><term>Mycophenolic Acid</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Mycophenolic Acid</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acide mycophénolique</term><term>Acides hydroxamiques</term><term>Immunosuppresseurs</term><term>Inhibiteurs de désacétylase d'histone</term><term>Tacrolimus</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide mycophénolique</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adult</term><term>Aged</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Transplantation Conditioning</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Conditionnement pour greffe</term><term>Femelle</term><term>Humains</term><term>Maladie aigüe</term><term>Maladie du greffon contre l'hôte</term><term>Mâle</term><term>Sujet âgé</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Transplantation homologue</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute graft-versus-host disease (GVHD) remains a barrier to more widespread application of allogeneic haemopoietic stem-cell transplantation. Vorinostat is an inhibitor of histone deacetylases and was shown to attenuate GVHD in preclinical models. We aimed to study the safety and activity of vorinostat, in combination with standard immunoprophylaxis, for prevention of GVHD in patients undergoing related-donor reduced-intensity conditioning haemopoietic stem-cell transplantation.</div></front></TEI><affiliations><list><country><li>Japon</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Californie</li><li>Indiana</li><li>Michigan</li><li>Missouri (État)</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>New York</li><li>Pittsburgh</li></settlement><orgName><li>Université Columbia</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Choi, Sung Won" sort="Choi, Sung Won" uniqKey="Choi S" first="Sung Won" last="Choi">Sung Won Choi</name></region><name sortKey="Beumer, Jan H" sort="Beumer, Jan H" uniqKey="Beumer J" first="Jan H" last="Beumer">Jan H. Beumer</name><name sortKey="Braun, Thomas" sort="Braun, Thomas" uniqKey="Braun T" first="Thomas" last="Braun">Thomas Braun</name><name sortKey="Chang, Lawrence" sort="Chang, Lawrence" uniqKey="Chang L" first="Lawrence" last="Chang">Lawrence Chang</name><name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R" last="Couriel">Daniel R. Couriel</name><name sortKey="Dipersio, John F" sort="Dipersio, John F" uniqKey="Dipersio J" first="John F" last="Dipersio">John F. Dipersio</name><name sortKey="Ferrara, James L M" sort="Ferrara, James L M" uniqKey="Ferrara J" first="James L M" last="Ferrara">James L M. Ferrara</name><name sortKey="Goldstein, Steve" sort="Goldstein, Steve" uniqKey="Goldstein S" first="Steve" last="Goldstein">Steve Goldstein</name><name sortKey="Hou, Guoqing" sort="Hou, Guoqing" uniqKey="Hou G" first="Guoqing" last="Hou">Guoqing Hou</name><name sortKey="Kitko, Carrie" sort="Kitko, Carrie" uniqKey="Kitko C" first="Carrie" last="Kitko">Carrie Kitko</name><name sortKey="Krijanovski, Oleg I" sort="Krijanovski, Oleg I" uniqKey="Krijanovski O" first="Oleg I" last="Krijanovski">Oleg I. Krijanovski</name><name sortKey="Lehmann, Michael H" sort="Lehmann, Michael H" uniqKey="Lehmann M" first="Michael H" last="Lehmann">Michael H. Lehmann</name><name sortKey="Levine, John E" sort="Levine, John E" uniqKey="Levine J" first="John E" last="Levine">John E. Levine</name><name sortKey="Magenau, John M" sort="Magenau, John M" uniqKey="Magenau J" first="John M" last="Magenau">John M. Magenau</name><name sortKey="Mapara, Markus Y" sort="Mapara, Markus Y" uniqKey="Mapara M" first="Markus Y" last="Mapara">Markus Y. Mapara</name><name sortKey="Paczesny, Sophie" sort="Paczesny, Sophie" uniqKey="Paczesny S" first="Sophie" last="Paczesny">Sophie Paczesny</name><name sortKey="Pawarode, Attaphol" sort="Pawarode, Attaphol" uniqKey="Pawarode A" first="Attaphol" last="Pawarode">Attaphol Pawarode</name><name sortKey="Reddy, Pavan" sort="Reddy, Pavan" uniqKey="Reddy P" first="Pavan" last="Reddy">Pavan Reddy</name><name sortKey="Stockerl Goldstein, Keith" sort="Stockerl Goldstein, Keith" uniqKey="Stockerl Goldstein K" first="Keith" last="Stockerl-Goldstein">Keith Stockerl-Goldstein</name><name sortKey="Sun, Yaping" sort="Sun, Yaping" uniqKey="Sun Y" first="Yaping" last="Sun">Yaping Sun</name><name sortKey="Yanik, Gregory A" sort="Yanik, Gregory A" uniqKey="Yanik G" first="Gregory A" last="Yanik">Gregory A. Yanik</name></country><country name="Japon"><noRegion><name sortKey="Tawara, Isao" sort="Tawara, Isao" uniqKey="Tawara I" first="Isao" last="Tawara">Isao Tawara</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Dinarello, Charles A" sort="Dinarello, Charles A" uniqKey="Dinarello C" first="Charles A" last="Dinarello">Charles A. Dinarello</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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